Publications

Bharucha, T., B. Gangadharan, R. Clarke, L. Gomez Fernandez, B. Yohan Arman, J. Walsby-Tickle, M. Deats, S. Mosca, Q. Lin, R. Stokes, S. Dunachie, H. Merchant, A. Dubot-Peres, C. Caillet, J. McCullagh, P. Matousek, N. Zitzmann and P. Newton, Repurposing rapid diagnostic tests to detect falsified vaccines in supply chains, Vaccine, 2024, 42 (7): p. 1506-1511.

 

Tax, G., K. Guay, L. Pantalone, M. Ceci, T. Soldà, C. Hitchman, J. Hill, S. Vasiljevic, A. Lia, C. Modenutti, K. Straatman, A. Santino, M. Molinari, N. Zitzmann, D. Hebert, P. Roversi and M. Trerotola, Rescue of secretion of rare-disease associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells, Traffic, 2024, 25 (1): e12927.

 

Arman, B.Y., J. Brun, M.L. Hill, N. Zitzmann and A. von Delft, An Update on SARS-CoV-2 Clinical Trial Results-What We Can Learn for the Next Pandemic, Int J Mol Sci, 2023, 25 (1): p. 354.

 

Boby, M., D. Fearon, M. Ferla, M. Filep, L. Koekemoer, M. Robinson, COVID Moonshot consortium (H. Achdout, A. Aimon, D. Alonzi, R. Arbon, J. Aschenbrenner, B. Balcomb, E. Bar-David, H. Barr, A. Ben-Shmuel, J. Bennett, V. Bilenko, B. Borden, P. Boulet, G. Bowman, L. Brewitz, J. Brun, S. Bvnbs, M. Calmiano, A. Carbery, D. Carney, E. Cattermole, E. Chang, E. Chernyshenko, A. Clyde, J. Coffland, G. Cohen, J. Cole, A. Contini, L. Cox, T. Croll, M. Cvitkovic, S. De Jonghe, A. Dias, K. Donckers, D. Dotson, A. Douangamath, S. Duberstein, T. Dudgeon, L. Dunnett, P. Eastman, N. Erez, C. Eyermann, M. Fairhead, G. Fate, O. Fedorov, R. Fernandes, L. Ferrins, R. Foster, H. Foster, L. Fraisse, R. Gabizon, A. García-Sastre, V. Gawriljuk, P. Gehrtz, C. Gileadi, C. Giroud, W. Glass, R. Glen, I. Glinert, A. Godoy, M. Gorichko, T. Gorrie-Stone, E. Griffen, A. Haneef, S. Hassell Hart, J. Heer, M. Henry, M. Hill, S. Horrell, Q. Huang, V. Huliak, M. Hurley, T. Israely, A. Jajack, J. Jansen, E. Jnoff, D. Jochmans, T. John, B. Kaminow, L. Kang, A. Kantsadi, P. Kenny, J. Kiappes, S. Kinakh, B. Kovar, T. Krojer, V. La, S. Laghnimi-Hahn, B. Lefker, H. Levy, R. Lithgo, I. Logvinenko, P. Lukacik, H. Macdonald, E. MacLean, L. Makower, T. Malla, P. Marples, T. Matviiuk, W. McCorkindale, B. McGovern, S. Melamed, K. Melnykov, O. Michurin, P. Miesen, H. Mikolajek, B. Milne, D. Minh, A. Morris, G. Morris, M. Morwitzer, D. Moustakas, C. Mowbray, A. Nakamura, J. Neto, J. Neyts, L. Nguyen, G. Noske, V. Oleinikovas, G. Oliva, G. Overheul, C. Owen, R. Pai, J. Pan, N. Paran, A. Payne, B. Perry, M. Pingle, J. Pinjari, B. Politi, A. Powell, V. Pšenák, I. Pulido, R. Puni, V. Rangel, R. Reddi, P. Rees, S. Reid, L. Reid, E. Resnick, E. Ripka, R. Robinson, J. Rodriguez-Guerra, R. Rosales, D. Rufa, K. Saar, K. Saikatendu, E. Salah, D. Schaller, J. Scheen, C. Schiffer, C. Schofield, M. Shafeev, A. Shaikh, A. Shaqra, J. Shi, K. Shurrush, S. Singh, A. Sittner, P. Sjö, R. Skyner, A. Smalley, B. Smeets, M. Smilova, L. Solmesky, J. Spencer, C. Strain-Damerell, V. Swamy, H. Tamir, J. Taylor, R. Tennant, W. Thompson, A. Thompson, S. Tomásio, C. Tomlinson, I. Tsurupa, A. Tumber, I. Vakonakis, R. van Rij, L. Vangeel, F. Varghese, M. Vaschetto, E. Vitner, V. Voelz, A. Volkamer, M. Walsh, W. Ward, C. Weatherall, S. Weiss, K. White, C. Wild, K. Witt, M. Wittmann, N. Wright, Y. Yahalom-Ronen, N. Yilmaz, D. Zaidmann, I. Zhang, H. Zidane, N. Zitzmann, S. Zvornicanin), J. Chodera, A. Lee, N. London, A. von Delft and F. von Delft, Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors, Science, 2023, 382(6671), eabo7201.

 

Mosca, S., Q. Lin, R. Stokes, T. Bharucha, B. Gangadharan, R. Clarke, L. Gomez Fernandez, M. Deats, J. Walsby-Tickle, B. Yohan Arman, S.R. Chunekar, K.D. Patil, S. Gairola, K. Van Assche, S. Dunachie, H.A. Merchant, R. Kuwana, A. Maes, J. McCullagh, C. Caillet, N. Zitzmann, P.N. Newton and P. Matousek, Innovative method for rapid detection of falsified COVID-19 vaccines through unopened vials using handheld Spatially Offset Raman Spectroscopy (SORS), Vaccine, 2023, 41 (47): p. 6960-6968.

 

Guay, K.P., R. Ibba, J.L. Kiappes, S. Vasiljevic, F. Boni, M. De Benedictis, I. Zeni, J.D. Le Cornu, M. Hensen, A.V. Chandran, A.L. Kantsadi, A.T. Caputo, J.I.B. Capurro, Y. Bayo, J.C. Hill, K. Hudson, A. Lia, J. Brun, S.G. Withers, M. Martí, E. Biasini, A. Santino, M. De Rosa, M. Milani, C.P. Modenutti, D.N. Hebert, N. Zitzmann and P. Roversi, A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint, iScience, 2023, 26 (10): 107919. 

 

Bharucha, T., B. Gangadharan, A. Kumar, A. Myall, N. Ayhan, B. Pastorino, A. Chanthongthip, M. Vongsouvath, M. Mayxay, O. Sengvilaipaseuth, O. Phonemixay, S. Rattanavong, D. O'Brien, I. Vendrell, R. Fischer, B. Kessler, L. Turtle, X. de Lamballerie, A. Dubot-Peres, P. Newton and N. Zitzmann, Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection, J Proteome Res, 2023, 22 (6): p. 1614-1629.

 

Tyrrell, B.E., A. Kumar, B. Gangadharan, D. Alonzi, J. Brun, M. Hill, T. Bharucha, A. Bosworth, V. Graham, S. Dowall, J.L. Miller and N. Zitzmann, Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays, Pathogens, 2023, 12 (3): p. 399.

 

Caputo, A.T., R. Ibba, J.D. Le Cornu, B. Darlot, M. Hensen, C.B. Lipp, G. Marcianò, S. Vasiljević, N. Zitzmann and P. Roversi, Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint, Front Mol Biosci, 2022, 9: p. 960248.

 

Bharucha, T., N. Ayhan, B. Pastorino, S. Rattanavong, M. Vongsouvath, M. Mayxay, A. Changthongthip, O. Sengvilaipaseuth, O. Phonemixay, N. Zitzmann, P.N. Newton, X. de Lamballerie and A. Dubot-Pérès, Immunoglobulin M seroneutralisation for improved confirmation of Japanese encephalitis virus infection in a flavivirus endemic area, Trans R Soc Trop Med Hyg, 2022, 116 (11): p. 1032–1042.

 

Domnick, A., C. Winter, L. Sušac, L. Hennecke, M. Hensen, N. Zitzmann, S. Trowitzsch, C. Thomas and R. Tampé, Molecular basis of MHC I quality control in the peptide loading complex, Nat Commun, 2022, 13 (1): p. 4701.

 

Robinson, P.C., D.F.L. Liew, H.L. Tanner, J.R. Grainger, R. Dwek, R.B. Reisler, L. Steinman, M. Feldmann, L. Ho, T. Hussell, P. Moss, D. Richards and N. Zitzmann, COVID-19 therapeutics: challenges and directions for the future, Proc Natl Acad Sci USA, 2022, 119 (15): e2119893119.

 

Dwek R.A., J.I. Bell, M. Feldmann and N Zitzmann, Host-targeting oral antiviral drugs to prevent pandemics, Lancet, 2022, 399 (10333): p. 1381-1382.

 

Bharucha, T., N. Zitzmann, P. Newton, A. Dubot-Pérès and L. Turtle, Flavivirus cross-reactivity would explain the apparent findings of Japanese encephalitis virus infection in Nigeria, J Immunoassay Immunochem, 2022, 43(4): p. 463-465.

 

Perera, N., J. Brun, D.S. Alonzi, B.E. Tyrrell, J.L. Miller and N. Zitzmann, Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells, Antiviral Res, 2022, 199, 105269.

 

Bharucha, T., B. Cleary, Al. Farmiloe, E. Sutton, H. Hayati, P. Kirkwood, L.A. Hamed, N. van Ginneken, K.S. Subramaniam, N. Zitzmann, G. Davies and L. Turtle, Mouse models of Japanese encephalitis virus infection: A systematic review and meta-analysis using a meta-regression approach, PLoS Negl Trop Dis, 2022, 16 (2): e0010116.

 

Jansen, J., K.C. Reimer, J.S. Nagai, F.S. Varghese, G.J. Overheul, M. de Beer, R. Roverts, D. Daviran, L.A.S. Fermin, B. Willemsen, M. Beukenboom, S. Djudjaj, S. von Stillfried, L.E. van Eijk, M. Mastik, M. Bulthuis, W. den Dunnen, H. van Goor, J.L. Hillebrands, S.H. Triana, T. Alexandrov, M.C. Timm, B.T. van den Berge, M. van den Broek, Q. Nlandu, J. Heijnert, E.M.J. Bindels, R.M. Hoogenboezem, F. Mooren, C. Kuppe, P. Miesen, K. Grünberg, T. Ijzermans, E.J. Steenbergen, J. Czogalla, M.F. Schreuder, N. Sommerdijk, A. Akiva, P. Boor, V.G. Puelles, J. Floege, T.B. Huber, COVID Moonshot consortium (H. Achdout, A. Aimon, E. Bar-David, H. Barr, A. Ben-Shmuel, J. Bennett, M.L. Boby, B. Borden, G.R. Bowman, J. Brun, S. BVNBS, M. Calmiano, A. Carbery, E. Cattermole, E. Chernychenko, J.D. Choder, A. Clyde, J.E. Coffland, G. Cohen, J. Cole, A. Contini, L. Cox, M. Cvitkovic, A. Dias, K. Donckers, D.L. Dotson, A. Douangamath, S. Duberstein, T. Dudgeon, L. Dunnett, P.K. Eastman, N. Erez, C.J. Eyermann, M. Fairhead, G. Fate, D. Fearon, O. Federov, M. Ferla, R.S. Fernandes, L. Ferrins, R. Foster, H. Foster, R. Gabizon, A. Garcia-Sastre, V.O. Gawriljuk, P. Gehrtz, C. Gileadi, C. Giroud, W.G. Glass, R. Glen, I. Glinert, A.S. Godoy, M. Gorichko, T. Gorrie-Stone, E.J. Griffen, S.H. Hart, J. Heer, M. Henry, M. Hill, S. Horrell, M.F.D. Hurley, T. Israely, A. Jajack, E. Jnoff, D. Jochmans, T. John, S. De Jonghe, A.L. Kantsadi, P.W. Kenny, J.L. Kiappes, L. Koekemoer, B. Kovar, T. Krojer, A.A. Lee, B.A. Lefker, H. Levy, N. London, P. Lukacik, H.B. Macdonald, B. Maclean, T.R. Malla, T. Matviiuk, W. McCorkindale, B.L. McGovern, S. Melamed, O. Michurin, H. Mikolajek, B.F. Milne, A. Morris, G.M. Morris, M.J. Morwitzer, D. Moustakas, A.M. Nakamura, J. Brandao, N. Johan, N. Luong, N. Gabriela, D. Noske, V. Oleinikovas, G. Oliva. G.J. Overheul, D. Owen, V. Psenak, R. Pai, J. Pan, N. Paran, B. Perry, M. Pingle, J. Pinjari, B. Politi, A. Powell, R. Puni, V.L. Rangel, R.N. Reddi, S.P. Reid, E. Resnick, E.G. Ripka, M.C. Robinson, R.P. Robinson, J. Rodriguez-Guerra, R.l. Rosales, D. Rufa, C. Schofield, M. Shafeev, A. Shaikh, J. Shi, K. Shurrush, S. Sing, A. Sittner, R. Skyner, A. Smalley, M.D. Smilova, L.J. Solmesky, J. Spencer, C. Strain-Damarell, V. Swamy, H. Tamir, R. Tennant, W. Thompson, A. Thompson, W. Thompson, S. Tomasia, A. Tumber, I. Vakonakis, R.P. van Rij, L. van Geel, F.S. Varghese, M. Vaschetto, E.B. Vitner, V. Voelz, A. Volkamer, F. von Delft, A. von Delft, M. Walsh, W. Ward, C. Weatherall, S. Weiss, K.M. White, C.F. Wild, M. Wittmann, N. Wright, Y. Yahalom-Ronen, D. Zaidmann, H. Zidane, N. Zitzmann), R.P. van Rij, I.G. Costa, R.K. Schneider, B. Smeets and R. Kramann, SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids, Cell Stem Cell, 2022, 29 (2): p. 217-231.

 

Karade, S., M. Hill, J.L. Kiappes, R. Manne, B. Aakula, N. Zitzmann, K. Warfield, A. Treston and R. Mariuzza, N-substituted valiolamine derivatives as potent inhibitors of endoplasmic reticulum α-glucosidases I and II with antiviral activity, J Med Chem, 2021, 64 (24): p. 18010-18024.

 

Smith, D.A., C. Fernandez-Antunez, A. Magri, R. Bowden, N. Chaturvedi, J. Fellay, J. McLauchlan, G.R. Foster, W.L. Irving, STOP-HCV Consortium (E. Barnes, J. Ball, D. Brainard, G. Burgess, G. Cooke, J. Dillon, G.R. Foster, C. Gore, N. Guha, R. Halford, C. Herath, C. Holmes, A. Howe, E. Hudson, W. Irving, S. Khakoo, P. Klenerman, D. Koletzki, N. Martin, B. Massetto, T. Mbisa, J. McHutchison, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C.C.A. Spencer, P. Targett-Adams, E. Thomson, P. Vickerman, N. Zitzmann), P. Simmonds, V. Pedergnana, S. Ramirez, J. Bukh, E. Barnes and M.A. Ansari, Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure, Nat Commun, 2021, 12 (1): 6105.

 

Sayce, A.C., F.O. Martinez, B.E. Tyrrell, N. Perera, M.L. Hill, R.A. Dwek, J.L. Miller and N. Zitzmann, Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response, Immunology, 2021, 164: p. 587-601.

 

Ragotte, R., D. Pulido, F. Donnellan, M. Hill, G. Gorini, H. Davies, J. Brun, K. McHugh, L. King, K. Skinner, K. Miura, C. Long, N. Zitzmann and S. Draper, Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein, mSphere, 2021, 6 (4): e0064721.

 

Dobrica, M.O., A. van Eerde, C. Tucureanu, A. Onu, L. Paruch, I. Caras, E. Vlase, H. Steen, S. Haugslien, D. Alonzi, N. Zitzmann, R. Bock, J. Dubuisson, C.I. Popescu, C. Stavaru, J.L. Clarke and N. Branza-Nichita, Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice, Plant Biotechnol J, 2021, 19(10): p. 2027–2039.

 

Brun, J., S. Vasiljevic, B. Gangadharan, M. Hensen, A.V. Chandran, M.L. Hill, J.L. Kiappes, R.A. Dwek, D.S. Alonzi, W.B. Struwe and N. Zitzmann, Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike, ACS Cent Sci, 2021, 7 (4): p. 586–593.

 

Modenutti, C.P., J.I. Blanco Capurro, R. Ibba, S. Vasiljević, M. Hensen, D.S. Alonzi, A.V. Chandran, J.C. Hill, J. Rushton, A. Kumar, S. Rubichi, A. Lia, G. Tax, L. Marti, A. Santino, M.A. Martí, N. Zitzmann and P. Roversi, Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose:glycoprotein glucosyl-transferase, Structure, 2021, 29 (4), p. 357-370.

 

El-Baba, T.J., C.A. Lutomski, A.L. Kantsadi, T.R. Malla, T. John, V. Mikhailov, J.R. Bolla, C.J. Schofield, N. Zitzmann, I. Vakonakis and C.V. Robinson, Allosteric Inhibition of the SARS-CoV-2 Main Protease: Insights from Mass Spectrometry Based Assays, Angew Chem Int Ed Engl, 2020, 59 (52): p. 23544-23548.

 

Sobala, Ł.F., P.Z. Fernandes, Z. Hakki, A.J. Thompson, J.D. Howe, M. Hill, N. Zitzmann, S. Davis, Z. Stamataki, T.D. Butters, D.S. Alonzi, S.J. Williams and G.J. Davies, Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target, Proc Natl Acad Sci USA, 2020, 117 (47): p. 29595-29601.

 

Bharucha, T., F.M. Shearer, M. Vongsouvath, M. Mayxay, X. de Lamballerie, P.N. Newton, N. Zitzmann, E. Gould and A. Dubot-Pérès, A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research, Int J Infect Dis, 2020, 95: p. 444-456.

 

Warfield, K., D. Alonzi, J. Hill, A. Caputo, P. Roversi, J.L. Kiappes, N. Sheets, M. Duchars, R. Dwek, J. Biggins, D.L. Barnard, S. Shresta, A. Treston and N. Zitzmann, Targeting ER α-glucosidase I with a single-dose iminosugar treatment protects against lethal influenza and dengue virus infections, J Med Chem, 2020, 63 (8): p. 4205-4214.

 

Fawsitt, C.G., P. Vickerman, G.S. Cooke and STOP HCV Consortium (E. Barnes, J. Ball, D. Brainard, G. Burgess, G.S. Cooke, J. Dillon, G. Foster, C. Gore, N. Guha, R. Halford, K. Whitby, C. Holmes, A. Howe, E. Hudson, S. Hutchinson, W. Irving, S. Khakoo, P. Klenerman, N. Martin, B. Massetto, T. Mbisa, J. McHutchison, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C. Spencer, E. Thomson, P. Vickerman, N. Zitzmann), Cost-effectiveness analysis of baseline testing for resistance-associated polymorphisms to optimize treatment outcome in genotype 1 noncirrhotic treatment-naïve patients with chronic hepatitis C virus, Value Health, 2020, 23 (2): p. 180-190.

 

Beier, L., J. Rossa, S. Woodhouse, S. Bergmann, H. Kramer, J. Protze, M. Eichner, A. Piontek, S. Vidal-y-Sy, J. Brandner, G. Krause, N. Zitzmann and J. Piontek, Use of modified Clostridium perfringens enterotoxin fragments for claudin targeting in liver and skin cells, Int J Mol Sci, 2019, 20 (19): p. 4774.

 

Bharucha, T., B. Gangadharan, A. Kumar, X. de Lamballerie, P. Newton, M. Winterberg, A. Dubot-Pérès and N. Zitzmann, Mass spectrometry-based proteomic techniques to identify cerebrospinal fluid biomarkers for diagnosing suspected central nervous system infections. A systematic review, J Infect, 2019, 79 (5): p. 407-418.

 

Wai Haan, Y., H. Al-Bajalan, E. Eukun Sage, D. Elangovan, N. Liana Mat Yajit, N. Maisarah Sarizan, N. Zitzmann, J. Kiappes, S. Aishah Hasbullah, N. Hadiani Ismail and M. Mohamed Mackeen, α-Glucosidase inhibition of lactone intermediates of the iminosugar deoxynojirimycin, Jurnal Teknologi, 2019, 81 (5): p. 121-128.

 

Ansari, M.A., E. Aranday-Cortes, C.L. Ip, A. da Silva Filipe, S.H. Lau, C. Bamford, D. Bonsall, A. Trebes, P. Piazza, V. Sreenu, V.M. Cowto, STOP-HCV Consortium (J. Ball, E. Barnes, G. Burgess, G. Cooke, J. Dillon, G. Foster, C. Gore, N. Guha, R. Halford, C. Holmes, E. Hudson, S. Hutchinson, W. Irving, S. Khakoo, P. Klenerman, N. Martin, T. Mbisa, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, S. Smith, C. Spencer, E. Thomson, P. Troke, P. Vickerman, N. Zitzmann), E. Hudson, R. Bowden, A.H. Patel, G.R. Foster, W.L Irving, K. Agarwal, E.C. Thomson, P. Simmonds, P. Klenerman, C. Holmes, E. Barnes, C.C. Spencer, J. McLauchlan and V. Pedergnana, Interferon lambda 4 impacts the genetic diversity of hepatitis C virus, Elife, 2019, 8, p. e42463.

 

Miller, J.L., M.L. Hill, J. Brun, A. Pountain, A.C. Sayce and N. Zitzmann, Iminosugars counteract the downregulation of the interferon gamma receptor by dengue virus, Antiviral Res, 2019, 170: 104551.

 

Oestringer, B., J.H. Bolivar, J.K. Claridge, L. Almanea, C. Chipot, F. Dehez, N. Holzmann, J.R. Schnell and N. Zitzmann, Hepatitis C virus sequence divergence preserves p7 viroporin structural and dynamic features, Sci Rep, 2019, 9 (1): p. 8383.

 

Zhuang, X., A. Magri, M. Hill, A.G. Lai, A. Kumar, S.B. Rambhatla, C.L. Donald, A.F. Lopez-Clavijo, S. Rudge, K. Pinnick, W.H. Chang, P.A.C. Wing, R. Brown, X. Qin, P. Simmonds, T.F. Baumert, D. Ray, A. Loudon, P. Balfe, M. Wakelam, S. Butterworth, A. Kohl, C.L. Jopling, N. Zitzmann and J.A. McKeating, The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication, Nat Commun, 2019, 10 (1): p. 377.

 

Kim, Y.C., C. Lopez-Camacho, J.E. Nettleship, N. Rahman, M.L. Hill, L. Silva-Reyes, G. Ortiz-Martinez, G. Figueroa-Aguilar, M.A. Mar, H. Vivanco-Cid, C.S. Rollier, N. Zitzmann, M.E. Viveros-Sandoval, R.J. Owens and A. Reyes-Sandoval, Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region, Virology Journal, 2018, 15: p. 193.

 

Oestringer, B.P., J.H. Bolivar, M. Hensen, J.K. Claridge, C. Chipot, F. Dehez, N. Holzmann, N. Zitzmann and J.R. Schnell, Re-evaluating the p7 viroporin structure, Nature, 2018, 562: p. E8-E18.

 

Marti, L., A. Lia, I.B. Reca, P. Roversi, A. Santino and N. Zitzmann, In planta preliminary screening of ER glycoprotein folding quality control (ERQC) modulators, Int J Mol Sci, 2018, 19 (7): p. E2135.

 

Roversi, P. and N. Zitzmann, How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint, Diamond Light Source Annual Review, 2018, p. 14-15.

 

Miller, J.L., B.E. Tyrrell and N. Zitzmann, Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus, Adv Exp Med Biol, 2018, 1062: p. 277-301.

 

Caputo, A.T., D.S. Alonzi, J.L. Kiappes, W.B. Struwe, A. Cross, S. Basu, B. Darlot, P. Roversi and N. Zitzmann, Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II, Adv Exp Med Biol, 2018, 1062: p. 265-276.

 

Chipot, C., F. Dehez, J.R. Schnell, N. Zitzmann, E. Pebay-Peyroula, L.J. Catoire, B. Miroux, E.R.S. Kunji, G. Veglia, T.A. Cross and P. Schanda, Perturbations of native membrane protein structure in alkyl phosphocholine detergents: A critical assessment of NMR and biophysical studies, Chem Rev, 2018, 118 (7): p. 3559-3607.

 

Behrens, A.J., A. Kumar, M. Medina-Ramirez, A. Cupo, K. Marshall, V.M. Cruz Portillo, D.J. Harvey, G. Ozorowski, N. Zitzmann, I.A. Wilson, A.B. Ward, W.B. Struwe, J.P. Moore, R.W. Sanders and M. Crispin, Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages, J Proteome Res, 2018, 17 (3): p. 987-999.

 

Kryshtafovych, A., R. Albrecht, A. Baslé, P. Bule, A.T. Caputo, A.L. Carvalho, K.L. Chao, R. Diskin, K. Fidelis, C.M.G.A. Fontes, F. Fredslund, H.J. Gilbert, C.W. Goulding, M.D. Hartmann, C.S. Hayes, O. Herzberg, J.C. Hill, A. Joachimiak, G.W. Kohring, R.I. Koning, L. Lo Leggio, M. Mangiagalli, K. Michalska, J. Moult, S. Najmudin, M. Nardini, V. Nardone, D. Ndeh, T.H. Nguyen, G. Pintacuda, S. Postel, M.J. van Raaij, P. Roversi, A. Shimon, A.K. Singh, E.J. Sundberg, K. Tars, N. Zitzmann and T. Schwede, Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016), Proteins, 2018, 86 (S1): p. 27-50.

 

Kiappes, J.L., M.L. Hill, D.S. Alonzi, J.L. Miller, R. Iwaki, A.C. Sayce, A.T. Caputo, A. Kato and N. Zitzmann, ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity, ACS Chem Biol, 2018, 13 (1): p. 60-65.

 

Kumar, A., B. Gangadharan, J. Cobbold, M. Thursz and N. Zitzmann, Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example, Sci Rep, 2017, 7 (1): p. 12072.

 

Roversi, P., L. Marti, A.T. Caputo, D.S. Alonzi, J.C. Hill, K.C. Dent, A. Kumar, M.D. Levasseur, A. Lia, T. Waksman, S. Basu, Y. Soto Albrecht, K. Qian, J.P. McIvor, C.B. Lipp, D. Siliqi, S. Vasiljević, S. Mohammed, P. Lukacik, M.A. Walsh, A. Santino and N. Zitzmann, Inter-domain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint, Proc Natl Acad Sci USA, 2017, 114: p. 8544-8549.

 

Tyrrell, B., A. Sayce, K. Warfield, J. Miller and N. Zitzmann, Iminosugars: Promising therapeutics for influenza infection, Crit Rev Microbiol, 2017, 43: p. 521-545.

 

Ansari, M.A., V. Pedergnana, C. L C Ip, A. Magri, A. Von Delft, D. Bonsall, N. Chaturvedi, I. Bartha, D. Smith, G. Nicholson, G. McVean, A. Trebes, P. Piazza, J. Fellay, G. Cooke, G.R. Foster, STOP-HCV Consortium (E. Barnes, J. Ball, D. Brainard, G. Burgess, G. Cooke, J. Dillon, G.R. Foster, C. Gore, N. Guha, R. Halford, C. Herath, C. Holmes, A. Howe, E. Hudson, W. Irving, S. Khakoo, P. Klenerman, D. Koletzki, N. Martin, B. Massetto, T. Mbisa, J. McHutchison, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C.C.A. Spencer, P. Targett-Adams, E. Thomson, P. Vickerman, N. Zitzmann), E. Hudson, J. McLauchlan, P. Simmonds, R. Bowden, P. Klenerman, E. Barnes and C.C.A. Spencer, Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus, Nat Genet, 2017, 49: p. 666-673.

 

Alonzi, D.S., K.A. Scott, R.A. Dwek and N. Zitzmann, Iminosugar antivirals: the therapeutic sweet spot, Biochem Soc Trans, 2017, 45 (2): p. 571-582.

 

Perera, N., J. Miller and N. Zitzmann, The role of the unfolded protein response in dengue virus pathogenesis, Cell Microbiol, 2017, 19: p. e12734.

 

Behrens, A.J., D.J. Harvey, E. Milne, A. Cupo, A. Kumar, N. Zitzmann, W.B. Struwe, J.P. Moore and M. Crispin, Molecular architecture of the cleavage-dependent mannose patch on a soluble HIV-1 envelope glycoprotein trimer, J Virol, 2016, 91 (2): e01894-16.

 

Miller, J.L., S.G. Spiro, S.D. Dowall, I. Taylor, A. Rule, D.S. Alonzi, A.C. Sayce, E. Wright, E.M. Bentley, R. Thom, G. Hall, R.A. Dwek, R. Hewson and N. Zitzmann, Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model, Plos One, 2016, 11 (11): e0167018.

 

Kumar, A., B. Gangadharan and N. Zitzmann, Multiple reaction monitoring and multiple reaction monitoring cubed based assays for the quantitation of apolipoprotein F, J Chromatogr B, 2016, 1033: p. 278-286.

 

Caputo, A.T., D.S. Alonzi, L. Marti, I.B. Reca, J.L. Kiappes, W.B. Struwe, A. Cross, S. Basu, E.D. Lowe, B. Darlot, A. Santino, P. Roversi and N. Zitzmann, Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals, Proc Natl Acad Sci U S A, 2016, 113 (32): p. E4630–E4638.

 

Walter, S., A. Bollenbach, J. Doerrbecker, S. Pfaender, R. Brown, G. Vieyres, C. Scott, R. Foster, A. Kumar, N. Zitzmann, S. Griffin, F. Penin, T. Pietschmann and E. Steinmann, Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7, J Virol, 2016, 90 (10): p. 5075-5089.

 

van Wilgenburg, B., I. Scherwitzl, E.C. Hutchinson, T. Leng, A. Kurioka, C. Kulicke, C. de Lara, S. Cole, S. Vasanawathana, W. Limpitikul, P. Malasit, D. Young, L. Denney, STOP-HCV consortium (E. Barnes, J. Ball, G. Burgess, G. Cooke, J. Dillon, C. Gore, G. Foster, N. Guha, R. Halford, C. Herath, C. Holmes, A. Howe, E. Hudson, W. Irving, S. Khakoo, D. Koletzki, N. Martin, T. Mbisa, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C. Spencer, P. Targett-Adams, E. Thomson, P. Vickerman, N. Zitzmann), M.D. Moore, P. Fabris, M.T. Giordani, Y.H. Oo, S.M. Laidlaw, L.B. Dustin, L.P. Ho, F.M. Thompson, N. Ramamurthy, J. Mongkolsapaya, C.B. Willberg, G.R. Screaton and P. Klenerman, MAIT cells are activated during human viral infections, Nat Commun, 2016, 7: p. 11653.

 

Crispin, M., A. Zeltina, N. Zitzmann and T.A. Bowden, Native functionality and therapeutic targeting of arenaviral glycoproteins, Curr Opin Virol, 2016, 18: p. 70-75.

 

Behrens, A.J., S. Vasiljevic, L.K. Pritchard, D.J. Harvey, R.S. Andev, S.A. Krumm, W.B. Struwe, A. Cupo, A. Kumar, N. Zitzmann, G.E. Seabright, H.B. Kramer, D.I.R. Spencer, L. Royle, J.H. Lee, P.J. Klasse, D.R. Burton, I.A. Wilson, A.B. Ward, R.W. Sanders, J.P. Moore, K.J. Doores, and M. Crispin, Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein, Cell Rep, 2016, 14 (11): p. 2695-2706.

 

Warfield, K.L., E.M. Plummer, A.C. Sayce, D.S. Alonzi, W. Tang, B.E. Tyrrell, M.L. Hill, A.T. Caputo, S.S. Killingbeck, P.R. Beatty, E. Harris, R. Iwaki, K. Kinami, D. Ide, J.L. Kiappes, A. Kato, M.D. Buck, K. King, W. Eddy, M. Khaliq, A. Sampath, A.M. Treston, R.A. Dwek, S.G. Enterlein, J.L. Miller, N. Zitzmann, U. Ramstedt and S. Shresta, Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4, Antiviral Res, 2016, 129: p. 93-98.

 

Sayce, A.C., D.S. Alonzi, S.S. Killingbeck, B.E. Tyrrell, M.L. Hill, A.T. Caputo, R. Iwaki, K. Kinami, D. Ide, J.L. Kiappes, P.R. Beatty, A. Kato, E. Harris, R.A. Dwek, J.L. Miller and N. Zitzmann, Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases - not glycolipid processing enzymes, PLoS Negl Trop Dis, 2016, 10 (3): p. e0004524.

 

Kato, A., Y. Hirokami, K. Kinami, Y. Tsuji, S. Miyawaki, I. Adachi, J. Hollinshead, R.J. Nash, J.L. Kiappes, N. Zitzmann, J.K. Cha, R.J. Molyneux, G.W.J. Fleet and N. Asano, Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors, Phytochemistry, 2015, 111: p. 124-131.

 

Hussain, S., J. Miller, D. Harvey, Y. Gu, P. Rosenthal, N. Zitzmann and J. McCauley, Strain-specific antiviral activity of iminosugars against human influenza A viruses, J Antimicrob Chemother, 2015, 70 (1): p. 136-152.

 

Dixon, E.V., J.K. Claridge, D.J. Harvey, K. Baruah, X. Yu, S. Vasiljevic, S. Mattick, L.K. Pritchard, B. Krishna, C.N. Scanlan, J.R. Schnell, M.K. Higgins, N. Zitzmann and M. Crispin, Fragments of bacterial endoglycosidase S and immunoglobulin G reveal subdomains of each that contribute to deglycosylation, J Biol Chem, 2014, 289 (20): p. 13876-13889.

 

Dalziel, M., M. Crispin, C.N. Scanlan, N. Zitzmann and R.A. Dwek, Emerging principles for the therapeutic exploitation of glycosylation, Science, 2014, 343 (6166): p. 1235681.

 

Meredith, L.W., N. Zitzmann and J.A. McKeating, Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission, Antiviral Res, 2013, 100 (3): p. 636-9.

 

Sayce, A.C., J.L. Miller and N. Zitzmann, Glucocorticosteroids as Dengue Therapeutics: Resolving Clinical Observations With a Primary Human Macrophage Model, Clin Infect Dis, 2013, 56 (6): p. 901–903.

 

Miller, J.L., R. Lachica, A.C. Sayce, J.P. Williams, M. Bapat, R. Dwek, P.R. Beatty, E. Harris and N. Zitzmann, Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo, Antimicrob Agents Chemother, 2012, 56 (12): p. 6379-6386.

 

Gangadharan, B., M. Bapat, J. Rossa, R. Antrobus, D. Chittenden, B. Kampa, E. Barnes, P. Klenerman, R.A. Dwek and N. Zitzmann, Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study, PLoS One, 2012, 7 (6): p. e39603.

 

Gangadharan, B., R. Antrobus, D. Chittenden, J. Rossa, M. Bapat, P. Klenerman, E. Barnes, R.A. Dwek and N. Zitzmann, New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients, J Proteome Res, 2011, 10 (5): p. 2643-2650.

 

Dorobantu, C., A. Macovei, C. Lazar, R.A. Dwek, N. Zitzmann and N. Branza-Nichita, Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein, J Virol, 2011, 85 (24): p. 13373-13383.

 

Whitfield, T., A.J. Miles, J.C. Scheinost, J. Offer, P. Wentworth, Jr., R.A. Dwek, B.A. Wallace, P.C. Biggin and N. Zitzmann, The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein, Mol Membr Biol, 2011, 28 (5): p. 254-264.

 

Gangadharan, B. and N. Zitzmann, Two dimensional gel electrophoresis using narrow pH 3-5.6 immobilised pH gradient strips identifies potential novel disease biomarkers in plasma or serum, Nature Protocol Exchange, 2011, doi:10.1038/protex.2011.261

 

Pollock, S., N.B. Nichita, A. Bohmer, C. Radulescu, R.A. Dwek and N. Zitzmann, Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells, Proc Natl Acad Sci U S A, 2010, 107 (40): p. 17176-17181.

 

Pollock, S., R. Antrobus, L. Newton, B. Kampa, J. Rossa, S. Latham, N.B. Nichita, R.A. Dwek and N. Zitzmann, Uptake and trafficking of liposomes to the endoplasmic reticulum, Faseb J, 2010, 24 (6): p. 1866-1878.

 

Sayce, A.C., J.L. Miller and N. Zitzmann, Targeting a host process as an antiviral approach against dengue virus, Trends Microbiol, 2010, 18 (7): p. 323-330.

 

Macovei, A., C. Radulescu, C. Lazar, S. Petrescu, D. Durantel, R.A. Dwek, N. Zitzmann and N.B. Nichita, Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells, J Virol, 2010, 84 (1): p. 243-253.

 

Billerbeck, E., Y.H. Kang, L. Walker, H. Lockstone, S. Grafmueller, V. Fleming, J. Flint, C.B. Willberg, B. Bengsch, B. Seigel, N. Ramamurthy, N. Zitzmann, E.J. Barnes, J. Thevanayagam, A. Bhagwanani, A. Leslie, Y.H. Oo, S. Kollnberger, P. Bowness, O. Drognitz, D.H. Adams, H.E. Blum, R. Thimme and P. Klenerman, Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties, Proc Natl Acad Sci U S A, 2010, 107 (7): p. 3006-3011.

 

Woodhouse, S.D., R. Narayan, S. Latham, S. Lee, R. Antrobus, B. Gangadharan, S. Luo, G.P. Schroth, P. Klenerman and N. Zitzmann, Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro, Hepatology, 2010, 52 (2): p. 443-453.

 

Knight, C.G., X. Zhang, A. Gunn, T. Brenner, R.W. Jackson, S.R. Giddens, S. Prabhakar, N. Zitzmann and P.B. Rainey, Testing temperature-induced proteomic changes in the plant-associated bacterium Pseudomonas fluorescens SBW25, Environ Microbiol, 2010, 3 (2): p. 396-402.

 

Senis, Y.A., R. Antrobus, S. Severin, A.F. Parguina, I. Rosa, N. Zitzmann, S.P. Watson and A. Garcia, Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions, J Thromb Haemost, 2009, 7 (10): p. 1718-1726.

 

Chew, C.F., R. Vijayan, J. Chang, N. Zitzmann and P.C. Biggin, Determination of pore-lining residues in the hepatitis C virus p7 protein, Biophys J, 2009, 96 (2): p. L10-12.

 

Narayan, R., B. Gangadharan, O. Hantz, R. Antrobus, A. Garcia, R.A. Dwek and N. Zitzmann, Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection, J Proteome Res, 2009, 8 (1): p. 118-122.

 

Luik, P., C. Chew, J. Aittoniemi, J. Chang, P. Wentworth, Jr., R.A. Dwek, P.C. Biggin, C. Venien-Bryan and N. Zitzmann, The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy, Proc Natl Acad Sci U S A, 2009, 106 (31): p. 12712-12716.

 

Antrobus, R., K. Grant, B. Gangadharan, D. Chittenden, R.D. Everett, N. Zitzmann and C. Boutell, Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome, Proteomics, 2009, 9 (15): p. 3913-3927.

 

Taylor, A., J.M. O'Leary, S. Pollock and N. Zitzmann, Conservation of hydrophobicity within viral envelope glycoproteins reveals a putative hepatitis C virus fusion peptide, Protein Pept Lett, 2009, 16 (7): p. 815-822.

 

Popescu, C.I., A.S. Grigorescu, R.A. Dwek and N. Zitzmann, The Hepatitis C Virus E2p7 localization and topology in a recombinant system, Rom J Biochem, 2009, 46 (2): p. 149-163.

 

Abd Hamid, U.M., L. Royle, R. Saldova, C.M. Radcliffe, D.J. Harvey, S.J. Storr, M. Pardo, R. Antrobus, C.J. Chapman, N. Zitzmann, J.F. Robertson, R.A. Dwek and P.M. Rudd, A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression, Glycobiology, 2008, 18 (12): p. 1105-1118.

 

Dunlop, D.C., A. Ulrich, B.J. Appelmelk, D.R. Burton, R.A. Dwek, N. Zitzmann and C.N. Scanlan, Antigenic mimicry of the HIV envelope by AIDS-associated pathogens, Aids, 2008, 22 (16): p. 2214-2217.

 

Pollock, S., R.A. Dwek, D.R. Burton and N. Zitzmann, N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery, Aids, 2008, 22 (15): p. 1961-1969.

 

Woodhouse, S.D., C. Smith, M. Michelet, N. Branza-Nichita, M. Hussey, R.A. Dwek and N. Zitzmann, Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells, Antimicrob Agents Chemother, 2008, 52 (5): p. 1820-1828.

 

Hughes, J.R., A.M. Meireles, K.H. Fisher, A. Garcia, P.R. Antrobus, A. Wainman, N. Zitzmann, C. Deane, H. Ohkura and J.G. Wakefield, A microtubule interactome: complexes with roles in cell cycle and mitosis, PLoS Biol, 2008, 6 (4): p. e98.

 

Scanlan, C.N., G.E. Ritchie, K. Baruah, M. Crispin, D.J. Harvey, B.B. Singer, L. Lucka, M.R. Wormald, P. Wentworth, Jr., N. Zitzmann, P.M. Rudd, D.R. Burton and R.A. Dwek, Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody, J Mol Biol, 2007, 372 (1): p. 16-22.

 

Lazar, C., D. Durantel, A. Macovei, N. Zitzmann, F. Zoulim, R.A. Dwek and N. Branza-Nichita, Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity, Antiviral Res, 2007, 76 (1): p. 30-37.

 

Gangadharan, B., R. Antrobus, R.A. Dwek and N. Zitzmann, Novel serum biomarker candidates for liver fibrosis in hepatitis C patients, Clin Chem, 2007, 53 (10): p. 1792-1799.

 

Senis, Y.A., M.G. Tomlinson, A. Garcia, S. Dumon, V.L. Heath, J. Herbert, S.P. Cobbold, J.C. Spalton, S. Ayman, R. Antrobus, N. Zitzmann, R. Bicknell, J. Frampton, K.S. Authi, A. Martin, M.J. Wakelam and S.P. Watson, A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein, Mol Cell Proteomics, 2007, 6 (3): p. 548-564.

 

Pardo, M., A. Garcia, R. Antrobus, M.J. Blanco, R.A. Dwek and N. Zitzmann, Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum, J Proteome Res, 2007, 6 (7): p. 2802-2811.

 

Steinmann, E., T. Whitfield, S. Kallis, R.A. Dwek, N. Zitzmann, T. Pietschmann and R. Bartenschlager, Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus, Hepatology, 2007, 46 (2): p. 330-338.

 

Scanlan, C.N., J. Offer, N. Zitzmann and R.A. Dwek, Exploiting the defensive sugars of HIV-1 for drug and vaccine design, Nature, 2007, 446 (7139): p. 1038-1045.

 

Pardo, M., R.A. Dwek and N. Zitzmann, Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery, Expert Rev Proteomics, 2007, 4 (2): p. 273-286.

 

Chapel, C., C. Garcia, B. Bartosch, P. Roingeard, N. Zitzmann, F.L. Cosset, J. Dubuisson, R.A. Dwek, C. Trepo, F. Zoulim and D. Durantel, Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors, J Gen Virol, 2007, 88 (Pt 4): p. 1133-1143.

 

Block, T.M., A.S. Mehta, P.M. Rudd, M.R. Wormald, D.R. Burton, I.A. Wilson, S.M. Petrescu, F.M. Platt, N. Zitzmann, T.D. Butters and R.A. Dwek, Glycobiology - discovery, diagnostics and drugs, Scion Publishing Ltd, UK, 2007.

 

Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek and N. Zitzmann, The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker, Int J Cancer, 2006, 119 (5): p. 1014-1022.

 

Knight, C.G., N. Zitzmann, S. Prabhakar, R. Antrobus, R. Dwek, H. Hebestreit and P.B. Rainey, Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network, Nat Genet, 2006, 38 (9): p. 1015-1022.

 

Garcia, A., Y.A. Senis, R. Antrobus, C.E. Hughes, R.A. Dwek, S.P. Watson and N. Zitzmann, A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter, Proteomics, 2006, 6 (19): p. 5332-5343.

 

Senis, Y.A., P.Y. Kim, G.L. Fuller, A. Garcia, S. Prabhakar, M.C. Wilkinson, H. Brittan, N. Zitzmann, R. Wait, D.A. Warrell, S.P. Watson, A.S. Kamiguti, R.D. Theakston, M.E. Nesheim and G.D. Laing, Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara, Biochim Biophys Acta, 2006, 1764 (5): p. 863-871.

 

Patargias, G., N. Zitzmann, R. Dwek and W.B. Fischer, Protein-protein interactions: modeling the hepatitis C virus ion channel p7, J Med Chem, 2006, 49 (2): p. 648-655.

 

Suzuki-Inoue, K., G.L. Fuller, A. Garcia, J.A. Eble, S. Pohlmann, O. Inoue, T.K. Gartner, S.C. Hughan, A.C. Pearce, G.D. Laing, R.D. Theakston, E. Schweighoffer, N. Zitzmann, T. Morita, V.L. Tybulewicz, Y. Ozaki and S.P. Watson, A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2, Blood, 2006, 107 (2): p. 542-549.

 

Popescu, C.I., A. Mares, L. Zdrentu, N. Zitzmann, R.A. Dwek and S.M. Petrescu, Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor, J Biol Chem, 2006, 281 (31): p. 21682-21689.

 

Macovei, A., N. Zitzmann, C. Lazar, R.A. Dwek and N. Branza-Nichita, Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity, Biochem Biophys Res Commun, 2006, 346 (3): p. 1083-1090.

 

Chapel, C., C. Garcia, P. Roingeard, N. Zitzmann, J. Dubuisson, R.A. Dwek, C. Trepo, F. Zoulim and D. Durantel, Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles, J Gen Virol, 2006, 87 (Pt 4): p. 861-871.

 

Zitzmann, N., J.M. O'Leary and R.A. Dwek, Glycobiology against viruses, The Biochemist, 2006, 28 (3): p. 23-26.

 

Chapel, C., N. Zitzmann, F. Zoulim and D. Durantel, Virus morphogenesis and viral entry as alternative targets for novel hepatitis C antivirals, Future Virology, 2006, 1 (2): p. 197-209.

 

Garcia, A., S.P. Watson, R.A. Dwek and N. Zitzmann, Applying proteomics technology to platelet research, Mass Spectrom Rev, 2005, 24 (6): p. 918-930.

 

Simmons, A., B. Gangadharan, A. Hodges, K. Sharrocks, S. Prabhakar, A. Garcia, R. Dwek, N. Zitzmann and A. McMichael, Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling, Immunity, 2005, 23 (6): p. 621-634.

 

Pardo, M., A. Garcia, B. Thomas, A. Pineiro, A. Akoulitchev, R.A. Dwek and N. Zitzmann, Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS, Proteomics, 2005, 5 (18): p. 4980-4993.

 

Zitzmann, N., T. Block, A. Methta, P. Rudd, D. Burton, I. Wilson, F. Platt, T. Butters and R.A. Dwek, Glycosylation: disease targets and therapy, Adv Exp Med Biol, 2005, 564 p. 1-2.

 

Pavlovic, D., W. Fischer, M. Hussey, D. Durantel, S. Durantel, N. Branza-Nichita, S. Woodhouse, R.A. Dwek and N. Zitzmann, Long alkylchain iminosugars block the HCV p7 ion channel, Adv Exp Med Biol, 2005, 564 p. 3-4.

 

Durantel, D., N. Branza-Nichita, S. Durantel, R.A. Dweek and N. Zitzmann, The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein, Adv Exp Med Biol, 2005, 564 p. 5-6.

 

Pardo, M., A. Pineiro, M. de la Fuente, A. Garcia, S. Prabhakar, N. Zitzmann, R.A. Dwek, M. Sanchez-Salorio, F. Dominguez and C. Capeans, Abnormal cell cycle regulation in primary human uveal melanoma cultures, J Cell Biochem, 2004, 93 (4): p. 708-720.

 

Garcia, A., S. Prabhakar, S. Hughan, T.W. Anderson, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit and N. Zitzmann, Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins, Blood, 2004, 103 (6): p. 2088-2095.

 

Garcia, A., S. Prabhakar, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit and N. Zitzmann, Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry, Proteomics, 2004, 4 (3): p. 656-668.

 

Branza-Nichita, N., C. Lazar, R.A. Dwek and N. Zitzmann, Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns), Biochem Biophys Res Commun, 2004, 319 (2): p. 655-662.

 

Durantel, D., S. Carrouee-Durantel, N. Branza-Nichita, R.A. Dwek and N. Zitzmann, Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus, Antimicrob Agents Chemother, 2004, 48 (2): p. 497-504.

 

Garcia, A., N. Zitzmann and S.P. Watson, Analyzing the platelet proteome, Semin Thromb Hemost, 2004, 30 (4): p. 485-489.

 

Chapel, C., I. Vuillermoz, N. Zitzmann, C. Trépo, F. Zoulim and D. Durantel, Rôle de la glycosylation des protéines d'enveloppe dans la morphogenèse des Flaviviridae et son inhibition par des antiviraux de nouvelles générations, Virologie, 2004, 8 p. 95-111.

 

Lazar, C., N. Zitzmann, R.A. Dwek and N. Branza-Nichita, The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions, Virology, 2003, 314 (2): p. 696-705.

 

Pavlovic, D., D.C. Neville, O. Argaud, B. Blumberg, R.A. Dwek, W.B. Fischer and N. Zitzmann, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives, Proc Natl Acad Sci U S A, 2003, 100 (10): p. 6104-6108.

 

Pleat, J., C. Dunkin and N. Zitzmann, Plastic surgery beyond the human genome, Plast Reconstr Surg, 2003, 111 (7): p. 2479-2480.

 

Dwek, R.A., T.D. Butters, F.M. Platt and N. Zitzmann, Targeting glycosylation as a therapeutic approach, Nat Rev Drug Discov, 2002, 1 (1): p. 65-75.

 

Branza-Nichita, N., C. Lazar, D. Durantel, R.A. Dwek and N. Zitzmann, Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus, Biochem Biophys Res Commun, 2002, 296 (2): p. 470-476.

 

Wu, S.F., C.J. Lee, C.L. Liao, R.A. Dwek, N. Zitzmann and Y.L. Lin, Antiviral effects of an iminosugar derivative on flavivirus infections, J Virol, 2002, 76 (8): p. 3596-3604.

 

Stumpf, M.P. and N. Zitzmann, RNA replication kinetics, genetic polymorphism and selection in the case of the hepatitis C virus, Proc Biol Sci, 2001, 268 (1480): p. 1993-1999.

 

Durantel, D., N. Branza-Nichita, S. Carrouee-Durantel, T.D. Butters, R.A. Dwek and N. Zitzmann, Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus, J Virol, 2001, 75 (19): p. 8987-8998.

 

Branza-Nichita, N., D. Durantel, S. Carrouee-Durantel, R.A. Dwek and N. Zitzmann, Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers, J Virol, 2001, 75 (8): p. 3527-3536.

 

Zitzmann, N., A. Mehlert, S. Carrouee, P.M. Rudd and M.A. Ferguson, Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei, Glycobiology, 2000, 10 (3): p. 243-249.

 

Chan-Fook, C., W.R. Jiang, B.E. Clarke, N. Zitzmann, C. Maidens, J.A. McKeating and I.M. Jones, Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity, Virology, 2000, 273 (1): p. 60-66.

 

Rudd, P.M., T.S. Mattu, N. Zitzmann, A. Mehta, C. Colominas, E. Hart, G. Opdenakker and R.A. Dwek, Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans, Biotechnol Genet Eng Rev, 1999, 16 p. 1-21.

 

Zitzmann, N., A.S. Mehta, S. Carrouee, T.D. Butters, F.M. Platt, J. McCauley, B.S. Blumberg, R.A. Dwek and T.M. Block, Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents, Proc Natl Acad Sci U S A, 1999, 96 (21): p. 11878-11882.